These bioactive implants allow mechanical interlocking with the surrounding tissue as well as promote biological fixation.
Biocompatible, osteoconductive titanium based implants has potentially substituted autologous bone grafts overcome their scarcity and various complications. metallic implants have a routine history of interfacial failure due to modulus mismatch with bone leading to stress-shielding, osteolysis and implant loosening. the fundamental concepts proposed by s. f. hulbert (1970) and larry hench (1969) have facilitated development of porous and bioactive implants which allow mechanical interlocking with the surrounding tissue as well as promote biological fixation. most of the conventional techniques for metal foam fabrication mostly generate pore size of >1mm which is unsuitable for biomedical application. present invention deals with stable slurry based processing of metallic foam with tailorable porosity upto 90%, pore size distribution from 50-600 micron and high pore interconnectivity. the respective features of titanium foam are not only advantageous for load-bearing applications; they are also useful for defence, automobile, aerospace applications. bioactivation of the surface of the metallic implant is a pre-requisite for higher cellular activity. a simple hydrothermal technique has been developed for creating nanostructures with simultaneous bioactivation of the porous titanium implants within two hours. combination of foam fabrication and bioactivation technique would add up newer dimensions to the titanium implants. both the developed processes are commercially viable and have the capacity to get translated into large scale manufacturing with minimum primary capital investment. studies revealed promising outcomes in terms of cell activity, bone in-growth as well as cartilage healing
Link: useful for defense, automobile, aerospace applications