Near infrared light-activable iron (III) complex as a remarkable and organelle-targeted anti-cancer agent for the photodynamic therapy application
photodynamic therapy (PDT) is one of the non-invasive techniques, involving localized activation of drug by irradiation of light of a certain wavelength. Metal-based complexes might serve as better targets to treat cancer. They have versatile coordination geometry and can involve in photo-redox pathways for the generation of reactive oxygen species (ROS) to kill cancer cells. Thus, a benzhydroxamate iron (III) complexes are prepared and their photocytotoxicity is evaluated. This complex exhibits preferential localization in the mitochondria and shows photocytotoxicity in red light in HeLa cancer cells. This complex is non-toxic under dark conditions, indicating the lead role of photoactivation to kill cancer cells. The complex is localized in the nucleus and mitochondria where it produces ROS upon irradiation. The mode of cell death is apoptosis, absent in cancer cells. Therefore, this project highlights the potential use of such biorelevant metal complexes as effective PDT agents.
Link: photodynamic therapy (PDT) is one of the non-invasive techniques, involving localized activation of drugs by irradiation of light of a certain wavelength.
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