About the Practice
Problem Statement:

A novel compound restores obsolete antibiotics to NDM-1 superbugs


A new compound that restores the efficacy of antibiotics, that have become ineffective because superbugs have developed resistance to them, has been developed. This new compound restores the efficacy (enhancement by >80-1,250 fold) of tetracycline antibiotics towards NDM1 (K. pneumoniae and E. coli) clinical isolates. The mechanism being that this new compound shuts down the energy required for the efflux pumps of bacteria that throw these antibiotics out. It also potentiates the antibiotics to more dangerous and tough to-kill biofilms of carbapenem-resistant A. baumannii, prevalent in hospital surfaces. The combination of this new compound and antibiotic effectively treats acute and chronic burn/surgical wound infections in mice models, caused by the carbapenem-resistant A. baumannii and KPC superbugs. It stops the bacteria from developing resistance to antibiotics and does not have the limitation of the development of bacterial resistance. Thus, it will revolutionize antibiotic therapy for the treatment of bacterial infections caused by antibiotic-resistant superbugs

About the Innovator

Knowledge Provider / Innovator: Divakara S S Murthy Uppu
Address: Rachenahalli Lake Rd, Jakkur
City: Bengaluru
State: Karnataka
PIN Code 560064

Email: diwakarmurthy2121@gmail.com
Contact No: 8022082716.0

Practice Details

Link: it will revolutionise the antibiotic therapy for treatment of bacterial infections caused by antibiotic-resistant superbugs
Problem Scale: Around The World
Blog Link 5:

News Link 5:

GIAN Reference: GIAN/UAL/1073

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