Multimechanistic polymer-based novel drug eluting stent coating
Stent Thrombosis (ST) and delayed reendothelialisation pose to be the major problems associated with currentlyavailable drug-eluting stents (DES). Therefore, a multi-mechanistic polymerbased novel DES coating is developed.Layered double hydroxide (LDH) nanoparticles have been successfully synthesised and are confirmed by FTIR, XRD, and TEM & Zeta potential. Significant drug loading (63%) has been observed in LDH nanoparticles, with a desirable controlled-drug release profile up to 16 days. PLA-PEG copolymer and Heparintagged PLA-PEG copolymer have been successfully synthesised and are confirmed by FTIR. Complete degradation of PLAPEG copolymer has been observed at around 90 days
Link: The developed stent surface coating is non-thrombogenic, anti-fouling and sufficiently hydrophilic.
Problem Scale: Around World