Problem Statement:

Targeted Theranostic Nanomedicines for Brain Cancer Therapy

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Detail:

The innovator developed targeted and controlled release nanomedicine systems including transferrin conjugated D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles and transferrirginine – glycine – aspartic acid (RGD) conjugated TPGS liposomes (i.e., transferrin conjugated liposomes and RGD conjugated liposomes) to deliver docetaxel (DTX) and quantum dots (QDs), simultaneously through receptor-mediated active delivery for brain cancer therapy. Innovator demonstrated that RGD or transferrin TPGS decorated theranostic liposomes were highly effective in delivering desired concentration of therapeutic agents and diagnostic agents across BBB without any signs of brain damage or edema in brain histopathology. These advanced platforms can diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In future, brain theranostics will be able to provide personalized treatment which can make brain cancer even curable or at least treatable at the earliest stage.

Knowledge Provider / Innovator: Sonali Singh Doharey, Rahul Pratap Singh, Poornima Agrawal
Address: Ajagara
City: Varanasi
State: Uttar Pradesh
PIN Code 221005

Problem Scale: Around the world
Blog Link 5:

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  https://www.academia.edu/19571234/Transferrin_receptor_targeted_vitamin_E_TPGS_micelles_for_brain_cancer_therapy_preparation_characterization_and_brain_distribution_in_rats