About the Practice
Problem Statement:

• It solves the problem of breast cancer into the human body which is very tough to be detected. • Prevention of breast cancer was nearly impossible for human to be done


The project has designed a novel drug formulation that inhibits breast cancer causing agent using carbinitrile group. Inhibition of aromatase, a cytochrome P‐450 enzyme responsible for biosynthesis of estrogens, is an effective approach for the prevention and treatment of estrogen‐dependent breast cancer.Carbonitrile containing compound shows enhancement in aromatase inhibiting activity. The present work aims to introduce carbinitrile group in ring‐D and to observe its impact on the aromatase inhibiting activity of the molecule. A novel A‐ and D‐ ring substituted steroid 16β‐cyano‐17β‐hydroxy‐4‐phenylthia‐4‐androsten‐3‐one (7) has been synthesized and evaluated for its potential as aromatase inhibitor using human placental microsomal preparation as the enzyme source and [1β‐3H] androstenedione as substrate

About the Innovator

Knowledge Provider / Innovator: Dr. Prafulla M. Sabale
Address: Parul Institute of Pharmacy, Vadodara
City: Vadodara
State: Gujarat
PIN Code 391760

Practice Details

GIAN Reference: GIAN/UAL/1318

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