• It solves the problem of breast cancer into the human body which is very tough to be detected. • Prevention of breast cancer was nearly impossible for human to be done
The project has designed a novel drug formulation that inhibits breast cancer causing agent using carbinitrile group. Inhibition of aromatase, a cytochrome P‐450 enzyme responsible for biosynthesis of estrogens, is an effective approach for the prevention and treatment of estrogen‐dependent breast cancer.Carbonitrile containing compound shows enhancement in aromatase inhibiting activity. The present work aims to introduce carbinitrile group in ring‐D and to observe its impact on the aromatase inhibiting activity of the molecule. A novel A‐ and D‐ ring substituted steroid 16β‐cyano‐17β‐hydroxy‐4‐phenylthia‐4‐androsten‐3‐one (7) has been synthesized and evaluated for its potential as aromatase inhibitor using human placental microsomal preparation as the enzyme source and [1β‐3H] androstenedione as substrate
Link: • The drug developed has the property to inhibit the production of cancer-causing agents into to human body. • This drug act as a preventive care for the breast cancer.
Manufacturing Capacity: d) Licensing
Problem Scale: Around the World.
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