Inhalable Multiparticulate Carrier Systems For Sustained And Targeted Delivery Of Isoniazid
About the Practice
Carrier system for drug delivery http://gyti.techpedia.in/files/GYTI-BOOK-color.pdf
Detail:
Inside lungs, the tuberculosis bacteria are taken up by the dust cells (alveolar macrophages), which are unable to digest the bacteria due to its unusual lipid rich cell wall. The bacteria multiply within the macrophage. The alveolar macrophages possess mannose (a protein) specific membrane receptors which can recognize and facilitate the internalization of carriers bearing mannose residues. Mannose decorated carrier systems for selective targeting to the alveolar macrophages have been developed. The results demonstrate that such carrier systems were efficiently phagocytosed by alveolar macrophages thereby delivering a higher payload of drug in comparison to the conventional dosage forms.
About the Innovator
Address: Uka Tarsadia University, Maliba Campus, Bardoli-Mahuva Road
City: Bardoli
State: Gujarat
PIN Code 394350
Email: sanjay.tiwari@utu.ac.in
Contact No: 7567503983.0
Practice Details
Link: CaCO3 particles, prepared by colloidal crystallization of CaCl2 and Na2CO3 solutions, were used as micro-templates for LbL deposition of CHI and NaALG. Subsequent to the deposition, templates were decomposed to obtain hollow microcapsules. Prepared microcapsules were subjected to physicochemical evaluations, drug release and stability studies. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232072/
Manufacturing Capacity: d) Licensing
Problem Scale: 1) India 2) Around the world
Blog Link 5:
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http://utu.ac.ichievements.html - •
https://www.coolavenues.com/b-school-updates/padmavibhushan-dr.-r.a.-mashelkar-gave-away-gyti-awards-at-iim-ahd-hosted-by-techpe - •
http://honeybee.org/honeybee_detailed.php?page=134&search_case= - •
https://app.utu.ac.in/NAAC/Criteria2/2.4.4/10N.pdf
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https://link.springer.com/article/10.1186/1465-9921-7-118 - • Jagannath C, Reddy VM, Kailasam S, O'Sullivan JF, Gangadharam
PR: - Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis : in vitro intracellular and in vivo studies. Am J Respir Crit Care Med 1995, 151:1083–1086. • Reddy VM, Nadadhur G, Daneluzzi D, O'Sullivan JF, Gangadharam
PR: - Anti tuberculosis activities of clofazimine and its new analogs B4154 and B4157. Antimicrob Agents Chemother 1996, 40:633–636.