Carrier system for drug delivery http://gyti.techpedia.in/files/GYTI-BOOK-color.pdf
Inside lungs, the tuberculosis bacteria are taken up by the dust cells (alveolar macrophages), which are unable to digest the bacteria due to its unusual lipid rich cell wall. The bacteria multiply within the macrophage. The alveolar macrophages possess mannose (a protein) specific membrane receptors which can recognize and facilitate the internalization of carriers bearing mannose residues. Mannose decorated carrier systems for selective targeting to the alveolar macrophages have been developed. The results demonstrate that such carrier systems were efficiently phagocytosed by alveolar macrophages thereby delivering a higher payload of drug in comparison to the conventional dosage forms.
Link: CaCO3 particles, prepared by colloidal crystallization of CaCl2 and Na2CO3 solutions, were used as micro-templates for LbL deposition of CHI and NaALG. Subsequent to the deposition, templates were decomposed to obtain hollow microcapsules. Prepared microcapsules were subjected to physicochemical evaluations, drug release and stability studies. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232072/
Manufacturing Capacity: d) Licensing
Problem Scale: 1) India 2) Around the world
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